Human Papillomavirus, Cytomegalovirus and Adeno-associated Virus 2 Infections in Pregnant and Non-Pregnant Women with Cervical Intraepithelial Neoplasia

摘要

Two hundred and eight cervical specimens from two groups of subjects, 165 non- and 53 pregnant women with CIN I-III were positive by PCR analyses for human papillomaviruses (HPVs), adeno-associated virus type 2 (AAV 2) and human cytomegalovirus (HCMV) in 67, 6 and 4.1% cases, respectively. The presence of AAV 2 infection was more frequently associated with pregnancy (17% versus 2.4%) and HPV-positive cervices (OR=6.358) than HCMV was. Increased HPV infection was strongly associated (P<0.001) with increased CIN grade, but there is no evidence that AAV 2 and HCMV infections have any impact on the CIN development.